Health Newsletter - #6
Gonadotrophin in the Treatment of Obese Women.
What so many investigators seem to overlook is that human chorionic gonadotrophin as such has no weight-reducing action whatsoever, nor has this ever been claimed to be the case. In fact, those quite exceptional patients who have the willpower to stay on a 500 calorie diet for forty days without human chorionic gonadotrophin often lose more weight than those who are receiving it; but they look drawn and haggard and regain their weight rapidly as soon as they stop dieting, because they have depleted normal fat reserves. The function of human chorionic gonadotrophin is exclusively to make drastic reduction over a short period of time safe, comfortable and entirely confined tc abnormal fat deposits. It is the latter peculiarity which accounts for the relative ease with which patients can hold their weight after this treatment, a fact which Dr. Craig's paper confirms.
Gonadotrophin in the Treatment of Obesity.
Our results are decidedly better than any we have hitherto found published elsewhere. Since obesity is a major health problem, we look for the day that a qualified and unbiased observer, who is experienced in the management of obesity, will come to Rome (perhaps under the auspices of your Society ?) to check our figures, to study our cases and to familiarize himself with our technic and all its details. This knowledge could then be applied to his own cases, without introducing arbitrary deviations of his own invention. Only when this is accomplished in a large series of cases can the value of our method be definitely established.
Function in Response to Glucose Ingestion in Obese Humans.
These results demonstrate in vivo, for the first time, the existence of differential hypothalamic function in lean and obese humans that may be secondary to obesity.
Effect of Human
Chorionic Gonadotropin on Blood Free Fatty Acids, Glucose and on the
Release of Free Fatty Acids from Subcutaneous adipose tissue in various
Groups of Newborns and Adults.
After administration of human chorionic gonadotropin (HCG; 500 IU/kg intramuscularly), the blood concentration of free fatty acids increases within 30 min in 1-day-old full-term, premature and small-for-date newborns. This effect does not appear in 1-day-old newborns of diabetic mothers with insulin-dependent diabetes, in 7-day-old newborns nor in adults. Glucose concentration rises in all groups of newborns, and no effect is observed in adults. In the in vitro study, HCG increases lipolysis in newborns’ adipose tissue.
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