Health Newsletter - #5
Alternative uses of hCG: Kaposi sarcoma.
The Effects of Preparations of Human Chorionic Gonadotropin on AIDS-Related Kaposi's Sarcoma
Kaposi's sarcoma is the most common cancer in patients with the acquired immunodeficiency syndrome (AIDS). Recently, certain preparations of human chorionic gonadotropin (hCG) have been shown to inhibit the growth of Kaposi's sarcoma cell lines in vitro and in immunodeficient mice.
Metabolic effects of hCG in adipose tissue metabolism. The action of hCG in adipose tissue metabolism.
Activities of hepatic enzymes related to adipose tissue metabolism were significantly modified after hCG. A demonstration of the relevance of hCG in the metabolism of fat.
Metabolic effects of human chorionic gonadotropin (HCG) in rats. Proc Soc Exp Biol Med. 1970 Nov;135(2):317-9. Fleigelman R, Fried GH.
Widespread distribution of hCG in normal human tissues: the safety of hCG.
By means of two assay systems, a beta chain human chorionic gonadotropin radioimmunoassay and a radioreceptor gonadotropin assay, a chorionic gonadotropin-like substance was demonstrated in extracts of liver and colon obtained at autopsy from three patients who died of nonneoplastic disease. ..........................Our data suggest that the genome responsible for the human chorionic gonadotropin production is not completely suppressed in adult nonendocrine tissues, and that the chorionic gonadotropin produced by colon and liver has little or no bioactivity in vivo because of its low carbohydrate content. Since many normal tissues produce chorionic gonadotropin, bioactivity may be modulated by regulation of carbohydrate content.
Widespread distribution of hCG in Nature: the safety of hCG.
Production of choriogonadotropin-like factor by a microorganism
It can be concluded from the present results that a microorganism produces a glycoprotein that is biologically active and has physicochemical properties similar to those of hCG.